反应详情

温度

80 °C

To a suspension of 5-(3-fluoro-4-nitrophenyl)-6-(4-fluorophenyl)-imidazo[2,1-b]oxazole (0.80 g, 2.2 mmol; Preparation #C.1) in ACN (6.0 mL) was added TEA (0.63 mL, 4.5 mmol) and 2,2-dimethylpropylamine (0.24 g, 2.7 mmol; TCI). The reaction was heated at about 80° C. for about 4 h then cooled to about 4° C. The resulting solid was filtered, washing with cold ACN (ca. 4° C.), and dried in a vacuum oven at about 55-65° C. to give the title compound (0.89 g, 96%): LC/MS (Table 1, Method b) Rt=2.62 min; MS m/z: 409.2 (M+H)+.

1. temperaturethen cooled to about 4° C
2. filtrationThe resulting solid was filtered
3. washwashing with cold ACN (ca. 4° C.)
4. customdried in a vacuum oven at about 55-65° C.