HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3S)-2-Oxo-3-tert-butoxycarbonylamino-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester → 2-tert-Butoxycarbonylamino-3-(3-nitropyridin-2-ylamino)propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3S)-2-Oxo-3-tert-butoxycarbonylamino-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester | HCID 54305289 | — |
| Reactant | 3-Chloro-3-nitro pyridine | HCID 66756668 | — |
| Reactant | Dicyclohexylamine 3-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)propanoate | HCID 70179098 | — |
| Product | 2-tert-Butoxycarbonylamino-3-(3-nitropyridin-2-ylamino)propionic acid | HCID 18465793 | — |
Reaction Steps
(2S) 2-tert-Butoxycarbonylamino-3-(3-nitropyridin-2-ylamino)propionic acid was prepared by a similar method as (2S) 2-tert-butoxycarbonylamino-3-(2-nitrophenyl-amino)propionic acid in Step A of the synthesis of 600a/103, except that 3-chloro-3-nitro pyridine was used instead of 2-fluoronitrobenzene, to give 4.05 g (64%) of a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790713B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-a1ba19dbb5164712877194e937820416 |
| Source note | uspto-grants-2010_09 |