HCID 54000108, compound → HCID 86602159, compound

Participants

Reaction Conditions

Reaction Steps

To trifluoromethanesulfonic acid 1-(4-chlorophthalazin-1-yl)-7-methoxynaphthalen-2-yl ester (5.0 g, 11 mmol) was added 3-((R)-α-amino-benzyl)-pentan-3-ol (10 g, 52 mmol). The suspension was stirred for 18 hrs at 120° C. After cooling to 25° C., the mixture was filtered following addition of dichloromethane. The filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (toluene/EtOAc 10:1 to 5:1) to give the title compound as a brown solid, which was triturated from hexane/diethyl ether to give 4.8 g (7.7 mmol) of a pure product as a mixture of diastereomers.

Provenance & Evidence