Sodium Chloride → EDTA disodium salt

HRID 1712009Notes

Reaction equation

HRID 1712009 reaction equation
[CH2:1]([N:12]([CH2:17][C:18]([OH:20])=[O:19])[CH2:13][C:14]([OH:16])=[O:15])[CH2:2][N:3]([CH2:8][C:9]([OH:11])=[O:10])[CH2:4][C:5]([OH:7])=[O:6].[Cl-].[Na+:22]>O>[CH2:2]([N:3]([CH2:8][C:9]([O-:11])=[O:10])[CH2:4][C:5]([OH:7])=[O:6])[CH2:1][N:12]([CH2:17][C:18]([O-:20])=[O:19])[CH2:13][C:14]([OH:16])=[O:15].[Na+:22].[Na+:22]

Participants

4

Reactant 2

HCID 5234Sodium ChlorideHCID 6049Ethylenediaminetetraacetic Acid

Product 1

HCID 8759EDTA disodium salt

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
65 °C

Procedure

Crude MTC product (MW 373.90, 10.0 g, ˜26.7 mmol) was fully dissolved in H2O (270 cm3). Ethylenediaminetetraacetic acid (EDTA) disodium salt dihydrate (MW 372.24, 1 g, 2.68 mmol, 0.1 equivalents) was added. The mixture was stirred at 65° C. for approximately 1 hour. The mixture was filtered by vacuum filtration. The filtrate was collected. Sodium chloride (NaCl, MW 57.96, 16 g, 0.276 mol, 10 equivalents) was added to the filtrate while stirring. The resulting precipitate was collected by vacuum filtration.

Workup

  1. filtrationThe mixture was filtered by vacuum filtration
  2. customThe filtrate was collected
  3. stirringwhile stirring
  4. filtrationThe resulting precipitate was collected by vacuum filtration

Sources & evidence

ORD record
ord-0a257f3385a3411c950ae4c1b7e8848b
Source dataset
uspto-grants-2010_09
Patent number
US07790881B2

Reaction notes

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