2-Fluorobenzoyl chloride → 3-Piperidinol, 1-(2-fluorobenzoyl)-3-(3-methoxyphenyl)-

HRID 1712024Notes

Reaction equation

HRID 1712024 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([C:19]2([OH:25])[CH2:24][CH2:23][CH2:22][NH:21][CH2:20]2)[CH:16]=[CH:17][CH:18]=1>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([N:21]1[CH2:22][CH2:23][CH2:24][C:19]([OH:25])([C:15]2[CH:16]=[CH:17][CH:18]=[C:13]([O:12][CH3:11])[CH:14]=2)[CH2:20]1)=[O:5]

Participants

3

Reactant 2

HCID 98082-Fluorobenzoyl chlorideHCID 116516763-(3-Methoxy-phenyl)-piperidine-3-ol

Product 1

HCID 117026563-Piperidinol, 1-(2-fluorobenzoyl)-3-(3-methoxyphenyl)-

Procedure

The compound of Example 1 was prepared according to the general preparation protocol A from 2-fluorobenzoyl chloride and 3-(3-methoxy-phenyl)-piperidine-3-ol.

Sources & evidence

ORD record
ord-99a54097ba7e4db486f1829c4d73135b
Source dataset
uspto-grants-2010_09
Patent number
US07790898B2

Reaction notes

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