4-Chlorobenzoyl chloride → (4-Chlorophenyl)-[3-hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]-methanone

HRID 1712040Notes

Reaction equation

HRID 1712040 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([C:19]2([OH:25])[CH2:24][CH2:23][CH2:22][NH:21][CH2:20]2)[CH:16]=[CH:17][CH:18]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:21]2[CH2:22][CH2:23][CH2:24][C:19]([OH:25])([C:15]3[CH:16]=[CH:17][CH:18]=[C:13]([O:12][CH3:11])[CH:14]=3)[CH2:20]2)=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 116516763-(3-Methoxy-phenyl)-piperidine-3-ol

Product 1

HCID 11537514(4-Chlorophenyl)-[3-hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]-methanone

Procedure

The compound of Example 19 was prepared according to the general preparation protocol A from 4-chlorobenzoyl chloride and 3-(3-methoxy-phenyl)-piperidine-3-ol.

Sources & evidence

ORD record
ord-b5d46c675957415ab01b6bceccfc61a5
Source dataset
uspto-grants-2010_09
Patent number
US07790898B2

Reaction notes

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