Phenylacetyl chloride → 1-[3-Hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]2phenyl ethanone

HRID 1712047Notes

Reaction equation

[C:1]1([CH2:7][C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([C:19]2([OH:25])[CH2:24][CH2:23][CH2:22][NH:21][CH2:20]2)[CH:16]=[CH:17][CH:18]=1>>[OH:25][C:19]1([C:15]2[CH:16]=[CH:17][CH:18]=[C:13]([O:12][CH3:11])[CH:14]=2)[CH2:24][CH2:23][CH2:22][N:21]([C:8](=[O:9])[CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:20]1

Participants

Reactant 2

HCID 7679Phenylacetyl chloride

HCID 116516763-(3-Methoxy-phenyl)-piperidine-3-ol

Product 1

HCID 115588821-[3-Hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]2phenyl ethanone

Procedure

The compound of Example 27 was prepared according to the general preparation protocol A from phenylacetyl chloride and 3-(3-methoxy-phenyl)-piperidine-3-ol.

Sources & evidence

ORD record: ord-0b23733431c34d3eb29de08fce58d2c9
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07790898B2

Reaction notes

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