2-Naphthoyl chloride → [3-Hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]-naphthalene-2-yl-methanone

HRID 1712048Notes

Reaction equation

HRID 1712048 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11](Cl)=[O:12].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([C:22]2([OH:28])[CH2:27][CH2:26][CH2:25][NH:24][CH2:23]2)[CH:19]=[CH:20][CH:21]=1>>[OH:28][C:22]1([C:18]2[CH:19]=[CH:20][CH:21]=[C:16]([O:15][CH3:14])[CH:17]=2)[CH2:27][CH2:26][CH2:25][N:24]([C:11]([C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:1]=2)=[O:12])[CH2:23]1

Participants

3

Reactant 2

HCID 752462-Naphthoyl chlorideHCID 116516763-(3-Methoxy-phenyl)-piperidine-3-ol

Product 1

HCID 11581303[3-Hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]-naphthalene-2-yl-methanone

Procedure

The compound of Example 28 was prepared according to the general preparation protocol A from naphthalene-2-carbonyl chloride and 3-(3-methoxy-phenyl)-piperidine-3-ol.

Sources & evidence

ORD record
ord-019105bb8c424b0c8d85dbd0d95162aa
Source dataset
uspto-grants-2010_09
Patent number
US07790898B2

Reaction notes

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