4-Methyl-3-nitrobenzoyl chloride → [3-Hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]-(4-methyl-3-nitrophenyl)-methanone

HRID 1712050Notes

Reaction equation

HRID 1712050 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([C:22]2([OH:28])[CH2:27][CH2:26][CH2:25][NH:24][CH2:23]2)[CH:19]=[CH:20][CH:21]=1>>[OH:28][C:22]1([C:18]2[CH:19]=[CH:20][CH:21]=[C:16]([O:15][CH3:14])[CH:17]=2)[CH2:27][CH2:26][CH2:25][N:24]([C:6]([C:5]2[CH:9]=[CH:10][C:2]([CH3:1])=[C:3]([N+:11]([O-:13])=[O:12])[CH:4]=2)=[O:7])[CH2:23]1

Participants

3

Reactant 2

HCID 663234-Methyl-3-nitrobenzoyl chlorideHCID 116516763-(3-Methoxy-phenyl)-piperidine-3-ol

Product 1

HCID 11501567[3-Hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]-(4-methyl-3-nitrophenyl)-methanone

Procedure

The compound of Example 30 was prepared according to the general preparation protocol A from 4-methyl-3-nitrobenzoyl chloride and 3-(3-methoxy-phenyl)-piperidine-3-ol.

Sources & evidence

ORD record
ord-ca2821a8df5c4bc7b06adc720582aea0
Source dataset
uspto-grants-2010_09
Patent number
US07790898B2

Reaction notes

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