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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1712166Generated: October 27, 2026

N-Methyl-1,3-propanediamine → 5-[3-(3-Methylamino-propyl)-ureido]-3-(2,3,6-trifluoro-4-methyl-benzyloxy)-isothiazole-4-carboxylic acid amide

https://huagongshe.com/reaction/1712166

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-Methyl-1,3-propanediamineHCID 80511—
Reactant[4-Carbamoyl-3-(2,3,6-trifluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl esterHCID 54053016—
Product5-[3-(3-Methylamino-propyl)-ureido]-3-(2,3,6-trifluoro-4-methyl-benzyloxy)-isothiazole-4-carboxylic acid amideHCID 10342704—

Reaction Steps

The title compound was prepared from [4-carbamoyl-3-(2,3,6-trifluoro-4-methyl-benzyloxy)-isothiazol-5-yl]-carbamic acid phenyl ester and N-methyl-propane-1,3-diamine by the procedure analogous to Example 1. MS (APCI, m/z): 432 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07790902B2
Source datasetuspto-grants-2010_09
ORD IDord-004522c1dbc84fe2bbbdc57b413d9c80
Source noteuspto-grants-2010_09