反应详情

A 60 ml Solumix/toluene (1:1) solution of 11.54 g (46.48 mmol) of the above 2-[2-(3-fluorophenyl)vinyl]naphthalene was added with 0.58 g of 5%-Pd/C and then stirred for 20 hours in an H2-atmosphere. The 5%-Pd/C was filtrated away from the reaction solution, and then the filtrate was condensed under a reduced pressure. The obtained gray solid of 11.18 g was purified with silica gel chromatography using toluene as the eluent to obtain a white solid of 11.05 g, which was recrystallized with a mixed solvent of Solumix/heptane in a ratio of 2:1 to obtain 10.43 g of 2-[2-(3-fluorophenyl)ethyl]naphthalene as white crystals.

1. filtrationThe 5%-Pd/C was filtrated away from the reaction solution
2. customcondensed under a reduced pressure
3. customThe obtained gray solid of 11.18 g was purified with silica gel chromatography
4. customto obtain a white solid of 11.05 g, which
5. customwas recrystallized with a mixed solvent of Solumix/heptane in a ratio of 2:1