HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1712200Generated: October 26, 2026
Toluene → (2S)-2-(3,4-Difluorophenyl)oxirane
https://huagongshe.com/reaction/1712200
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (alphaS)-alpha-(Chloromethyl)-3,4-difluorobenzenemethanol | HCID 25324204 | — |
| Solvent | Water | HCID 962 | — |
| Product | (2S)-2-(3,4-Difluorophenyl)oxirane | HCID 30070539 | 96% |
Reaction Steps
A mixture of (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol (net 11.47 g, 59.5 mmol), toluene (25.23 g), sodium hydroxide (2.53 g, 1.06 molar equivalents) and water (24.25 g) was stirred and heated at 40° C. for 1 hour. The organic layer was separated, washed with water, and concentrated under reduced pressure. (2S)-2-(3,4-difluorophenyl)oxirane was obtained as resultant concentrate (net 8.94 g, yield: 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07790927B2 |
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| Source dataset | uspto-grants-2010_09 |
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| ORD ID | ord-eaf7a14bee3549f791422820e3815e98 |
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| Source note | uspto-grants-2010_09 |
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