1,2,4,5-Tetrafluorobenzene → (2,3,5,6-Tetrafluorophenyl)methanamine
Reaction equation
FC1C(F)=CC(F)=C(F)C=1.[F:11][C:12]1[C:19]([F:20])=[CH:18][C:17]([F:21])=[C:16]([F:22])[C:13]=1[C:14]#[N:15]>>[F:11][C:12]1[C:19]([F:20])=[CH:18][C:17]([F:21])=[C:16]([F:22])[C:13]=1[CH2:14][NH2:15]Participants
3
Procedure
From the toluene extract, a small amount of a sample was withdrawn, and it was subjected to GC analysis. As a result of the analysis, a peak of the tetrafluoroterephthalonitrile as a raw material was below the detection limit, and tetrafluoroterephthalaldehyde was obtained in an amount of only 42.2 mol %. The amount of 2,3,5,6-tetrafluorobenzene was 1.75 mol %, and the amount of 2,3,5,6-tetrafluorobenzonitrile was 1.40 mol %. On the other hand, the aqueous phase was neutralized and then subjected to GC analysis. As a result of the analysis, presence of 28.1 mol % of 2,3,5,6-tetrafluorobenzylamine was confirmed. The results are set forth in Table 2.
Sources & evidence
- ORD record
- ord-ce3ef439df174b45a50f65a22d9719aa
- Source dataset
- uspto-grants-2010_09
- Patent number
- US07790931B2
Reaction notes
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