反应详情

Potassium tert-butoxide (2.2 g, 19.3 mmol) is added to a solution of 1,3-dichloroisoquinoline (3.2 g, 16.12 mmol) in toluene (40 mL). The solution is then heated at reflux, cooled to ambient temperature, and filtered through a silica pad. The filtrate is concentrated under reduced pressure and the residual yellow liquid is purified by distillation (210° C., 0.1 mm Hg), yielding 1-tert-butoxy-3-chloroisoquinoline (3.4 g, 89%).

1. temperatureThe solution is then heated
2. temperatureat reflux
3. filtrationfiltered through a silica pad
4. concentrationThe filtrate is concentrated under reduced pressure
5. distillationthe residual yellow liquid is purified by distillation (210° C., 0.1 mm Hg)