1-Chloro-3-methoxypropane → [3-Methoxy-5-(3-methoxypropoxy)phenyl]methanol

HRID 1712241Notes

Reaction equation

HRID 1712241 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([OH:11])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.Cl[CH2:13][CH2:14][CH2:15][O:16][CH3:17]>>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([CH2:2][OH:1])[CH:4]=[C:5]([O:11][CH2:13][CH2:14][CH2:15][O:16][CH3:17])[CH:6]=1

Participants

3

Reactant 2

HCID 1189271-Chloro-3-methoxypropaneHCID 5929863-(Hydroxymethyl)-5-methoxyphenol

Product 1

HCID 59817758[3-Methoxy-5-(3-methoxypropoxy)phenyl]methanol

Procedure

Analogously to Method F, 3.15 g of 3-hydroxymethyl-5-methoxyphenol are reacted with 1-chloro-3-methoxypropane. The title compound is obtained as a slightly yellowish oil. Rf=0.27 (1:1 EtOAc-heptane). Rt=3.23.

Sources & evidence

ORD record
ord-68e82f1d490a4931b1901124a8b2a7e1
Source dataset
uspto-grants-2010_09
Patent number
US07790715B2

Reaction notes

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