2-Bromo-1-bromomethyl-3-nitrobenzene → Benzyl 3-(2-bromo-3-nitrobenzyloxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	2-Bromo-1-bromomethyl-3-nitrobenzene	HCID 11066342	—
Reactant	Benzyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate	HCID 68499596	—
Product	Benzyl 3-(2-bromo-3-nitrobenzyloxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate	HCID 68502204	—

Reaction Steps

Analogously to Method D, 1.30 g of benzyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy)propoxy]-phenyl}piperidine-1-carboxylate (Example 10f) and 1.0 g of 2-bromo-1-bromomethyl-3-nitrobenzene are reacted. The title compound is obtained as a yellowish oil. Rf=029 (1:1 EtOAc-heptane); Rt=6.12.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07790715B2
Source dataset	uspto-grants-2010_09
ORD ID	ord-cbd5331b2c0f4184860029ab0cf4c87c
Source note	uspto-grants-2010_09