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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1712281Generated: November 1, 2026

Tert-butyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy) propoxy]phenyl}piperidine-1-carboxylate → tert-Butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-[1-(3-methoxypropyl)-1H-indazol-6-ylmethoxy]piperidine-1-carboxylate

https://huagongshe.com/reaction/1712281

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-butyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy) propoxy]phenyl}piperidine-1-carboxylateHCID 15546933—
ReactantHCID 68506313HCID 68506313—
Producttert-Butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-[1-(3-methoxypropyl)-1H-indazol-6-ylmethoxy]piperidine-1-carboxylateHCID 68634541—

Reaction Steps

Analogously to Method D, 0.390 g of tert-butyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy) propoxy]phenyl}piperidine-1-carboxylate and 0.199 g of 6-chloromethyl-1-(3-methoxypropyl)-1H-indazole are reacted. The title compound is obtained as a colourless oil. Rf=0.31 (2:1 EtOAc-heptane); Rt=6.12.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07790715B2
Source datasetuspto-grants-2010_09
ORD IDord-87efca4e28194a27b317b56fa87c4415
Source noteuspto-grants-2010_09