Azobisisobutyronitrile → HCID 68497857, compound

Participants

Reaction Steps

The mixture of 25.0 g of methyl 2-(3-ethoxypropoxy)-4-methylbenzoate, 18.4 g of N-bromo-succinimide, 1.65 g of 2,2′-azobis(2-methylpropionitrile) and 2.46 g of dibenzoyl peroxide in 1.2 l of carbon tetrachloride is heated to reflux with stirring and stirred over 3 hours (succinimide crystallizes out). The reaction mixture is cooled and clarified by filtration, and the filtrate is concentrated by evaporation. The title compound is obtained as a slightly orange oil from the residue by means of flash chromatography (SiO2 60F). Rf=0.30 (1:1 EtOAc-heptane); Rt=17.10 (II).

Provenance & Evidence