HCID 19593725, compound → tert-Butyl 3-{1(R)-[2-(2-acetylaminoethyl)phenylcarbamoyl]ethoxy}-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate

HRID 1712303Notes

Reaction equation

HRID 1712303 reaction equation
[C:1]([C@H:4]([O:6][CH:7]1[CH:12]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][O:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[O:31][CH3:32])=[CH:15][CH:14]=2)[CH2:11][CH2:10][N:9]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:8]1)[CH3:5])([OH:3])=O.[NH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=1[CH2:47][CH2:48][NH:49][C:50](=[O:52])[CH3:51]>>[C:50]([NH:49][CH2:48][CH2:47][C:42]1[CH:43]=[CH:44][CH:45]=[CH:46][C:41]=1[NH:40][C:1]([C@H:4]([O:6][CH:7]1[CH:12]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][O:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[O:31][CH3:32])=[CH:15][CH:14]=2)[CH2:11][CH2:10][N:9]([C:33]([O:35][C:36]([CH3:38])([CH3:39])[CH3:37])=[O:34])[CH2:8]1)[CH3:5])=[O:3])(=[O:52])[CH3:51]

Participants

3

Reactant 2

HCID 19593725HCID 19593725, compoundHCID 68504293tert-butyl 3-(1(R)-carboxyethoxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1 carboxylate

Product 1

HCID 68505420tert-Butyl 3-{1(R)-[2-(2-acetylaminoethyl)phenylcarbamoyl]ethoxy}-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate

Procedure

Analogously to Example 3a, 0.165 g of tert-butyl 3-(1(R)-carboxyethoxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1 carboxylate and 0.066 g of N-[2-(2-aminophenyl)ethyl]acetamide (Example 34c) are reacted. The title compound is obtained as a yellow oil. Rf=0.22 (95:5 dichloromethane-methanol); Rt=5.34.

Sources & evidence

ORD record
ord-ca5d1cfe45964e079b6f55d44f047e5c
Source dataset
uspto-grants-2010_09
Patent number
US07790715B2

Reaction notes

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