2-Pyrrolidone → tert-Butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-(2-{2-[2-(2-oxopyrrolidin-1-yl)ethyl]phenoxy}ethoxy)piperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	2-Pyrrolidone	HCID 12025	—
Reactant	Tert-butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-(2-{2-[2-(toluene-4-sulphonyloxy)ethyl]phenoxy}-ethoxy)piperidine-1-carboxylate	HCID 86609986	—
Product	tert-Butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-(2-{2-[2-(2-oxopyrrolidin-1-yl)ethyl]phenoxy}ethoxy)piperidine-1-carboxylate	HCID 68571695	—

Reaction Steps

Analogously to Example 27a, 0.20 g of tert-butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-(2-{2-[2-(toluene-4-sulphonyloxy)ethyl]phenoxy}ethoxy)piperidine-1-carboxylate (Example 26b) and 0.19 ml of pyrrolidin-2-one are reacted. The title compound is obtained as a colourless oil. Rf=0.10 (2:1 EtOAc-heptane); Rt=5.88.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07790715B2
Source dataset	uspto-grants-2010_09
ORD ID	ord-c515436d159d430f8854a7152f894a07
Source note	uspto-grants-2010_09