HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → tert-Butyl 3-[1-(3-methoxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethoxy]-4-[4-(4-o-tolyloxybutoxy)phenyl]piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Tert-butyl 4-(4-hydroxyphenyl)-3-[1-(3-methoxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethoxy]piperidine-1-carboxylate | HCID 68501561 | — |
| Product | tert-Butyl 3-[1-(3-methoxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethoxy]-4-[4-(4-o-tolyloxybutoxy)phenyl]piperidine-1-carboxylate | HCID 68499329 | — |
Reaction Steps
Analogously to Method I, 0.160 g of tert-butyl 4-(4-hydroxyphenyl)-3-[1-(3-methoxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-ylmethoxy]piperidine-1-carboxylate (Example 44d) and 0.099 g of 14-bromobutoxy)-2-methylbenzene are reacted. The title compound is obtained as a colourless oil. Rf=0.33 (2:1 EtOAc-heptane); Rt=6.34.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790715B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-6ca562cb06d74ddfb9ac3a58a8ddf6e8 |
| Source note | uspto-grants-2010_09 |