4-Methoxybutanoyl chloride → HCID 68503209, compound

HRID 1712435Notes

Reaction equation

HRID 1712435 reaction equation
[NH2:1][C:2]1[CH:42]=[CH:41][C:40]([F:43])=[CH:39][C:3]=1[CH2:4][O:5][CH:6]1[CH:11]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[O:30][CH3:31])=[CH:14][CH:13]=2)[CH2:10][CH2:9][N:8]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH2:7]1.[CH3:44][O:45][CH2:46][CH2:47][CH2:48][C:49](Cl)=[O:50]>>[F:43][C:40]1[CH:41]=[CH:42][C:2]([NH:1][C:49](=[O:50])[CH2:48][CH2:47][CH2:46][O:45][CH3:44])=[C:3]([CH:39]=1)[CH2:4][O:5][CH:6]1[CH:11]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[O:30][CH3:31])=[CH:14][CH:13]=2)[CH2:10][CH2:9][N:8]([C:32]([O:34][C:35]([CH3:37])([CH3:38])[CH3:36])=[O:33])[CH2:7]1

Participants

3

Reactant 2

HCID 127949894-Methoxybutanoyl chlorideHCID 68499727HCID 68499727, compound

Product 1

HCID 68503209HCID 68503209, compound

Procedure

Analogously to Example 116b, 0.487 g of tert-butyl 3-(2-amino-5-fluorobenzyloxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate and 0.322 g of 4-methoxybutyryl chloride are reacted. The title compound is obtained as a beige oil. Rf=0.22 (1:1 EtOAc-heptane); Rt=5.73.

Sources & evidence

ORD record
ord-6537a9e9cea04ad68e00da4cd4fd0a51
Source dataset
uspto-grants-2010_09
Patent number
US07790715B2

Reaction notes

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