2-hydroxy-N-(2-methoxyethyl)benzamide → tert-Butyl 3-{2-[2-(2-cyanoethyl)phenoxy]ethoxy}-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	2-hydroxy-N-(2-methoxyethyl)benzamide	HCID 19378278	—
Reactant	Tert-butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-[2-(toluene-4-sulphonyloxy)ethoxy]piperidine-1-carboxylate	HCID 86609984	—
Product	tert-Butyl 3-{2-[2-(2-cyanoethyl)phenoxy]ethoxy}-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate	HCID 68501910	—

Reaction Steps

Analogously to Method G. 0.456 g of tert-butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-[2-(toluene-4-sulphonyloxy)ethoxy]piperidine-1-carboxylate (Example 14b) and 027 g of 2-hydroxy-N-(2-methoxyethyl)benzamide are reacted. The title compound is obtained as a yellow oil. Rf=0.40 (1:1 EtOAc-heptane); Rt=5.60.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07790715B2
Source dataset	uspto-grants-2010_09
ORD ID	ord-af3b9ff78c2a4921b0d55ec56d642367
Source note	uspto-grants-2010_09