HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Bromopropoxy)-3-chlorobenzene → Tert-butyl 4-{4-[3-(3-chlorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Bromopropoxy)-3-chlorobenzene | HCID 2734929 | — |
| Reactant | (3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate | HCID 21713087 | — |
| Product | Tert-butyl 4-{4-[3-(3-chlorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate | HCID 68505679 | — |
Reaction Steps
Analogously to Method I, 0.750 g of tert-butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate and 0.832 g of 1-(3-bromopropoxy)-3-chlorobenzene are reacted. The title compound is obtained as a slightly yellowish oil. Rf=0.30 (1:2 EtOAc-heptane); Rt=5.55.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790715B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-93a9392b475c46ea96839d99281bd0c0 |
| Source note | uspto-grants-2010_09 |