methyl N-[2-(4-fluoro-2-hydroxyphenyl)ethyl]carbamate → tert-Butyl 3-[2-[5-fluoro-2-(2-methoxycarbonylaminoethyl)phenoxy]ethoxy}-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	methyl N-[2-(4-fluoro-2-hydroxyphenyl)ethyl]carbamate	HCID 68503523	—
Reactant	Tert-butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-[2-(toluene-4-sulphonyloxy)ethoxy]piperidine-1-carboxylate	HCID 86609984	—
Product	tert-Butyl 3-[2-[5-fluoro-2-(2-methoxycarbonylaminoethyl)phenoxy]ethoxy}-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate	HCID 68502017	—

Reaction Steps

Analogously to Method G, 0.40 g of tert-butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-[2-(toluene-4-sulphonyloxy)ethoxy]piperidine-1-carboxylate (Example 14b) and 0.26 g of methyl N-[2-(4-fluoro-2-hydroxyphenyl)ethyl]carbamate are reacted. The title compound is obtained as a yellow oil. Rf=0.42 (1:1 EtOAc-heptane); Rt=5.93.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07790715B2
Source dataset	uspto-grants-2010_09
ORD ID	ord-73c8bd996188490498c235dfb2d67946
Source note	uspto-grants-2010_09