Benzyl 3-hydroxy-4-(4-hydroxyphenyl)piperidinecarboxylate → HCID 68497866, compound

HRID 1712508Notes

Reaction equation

HRID 1712508 reaction equation
[OH:1][CH:2]1[CH:7]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH2:6][CH2:5][N:4]([C:15]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:16])[CH2:3]1.C1(C)C=CC(S(O[CH2:35][CH2:36][O:37][CH2:38][C:39]2[CH:44]=[C:43]([F:45])[CH:42]=[CH:41][C:40]=2[F:46])(=O)=O)=CC=1>>[F:46][C:40]1[CH:41]=[CH:42][C:43]([F:45])=[CH:44][C:39]=1[CH2:38][O:37][CH2:36][CH2:35][O:14][C:11]1[CH:10]=[CH:9][C:8]([CH:7]2[CH2:6][CH2:5][N:4]([C:15]([O:17][CH2:18][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[O:16])[CH2:3][CH:2]2[OH:1])=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 68500730Benzyl 3-hydroxy-4-(4-hydroxyphenyl)piperidinecarboxylateHCID 86610012HCID 86610012, compound

Product 1

HCID 68497866HCID 68497866, compound

Procedure

Analogously to Method I, 0.665 g of benzyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate and 0.824 g of 2-(2,5-difluorobenzyloxy)ethyl toluene-4-sulphonate are reacted. The title compound is obtained as a colourless oil. Rf=0.21 (1:1 EtOAc-heptane). Rt=5.01.

Sources & evidence

ORD record
ord-a7820d6ee91d48d2bd682e6a7f499933
Source dataset
uspto-grants-2010_09
Patent number
US07790715B2

Reaction notes

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