1-(3-Bromopropoxy)-3-fluorobenzene → tert-Butyl 3-{2-[2-(2-acetylaminoethyl)-5-fluorophenoxy]ethoxy}-4-{4-[3-(3-fluorophenoxy)propoxy]phenyl}piperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	1-(3-Bromopropoxy)-3-fluorobenzene	HCID 23294433	—
Reactant	HCID 68504580	HCID 68504580	—
Product	tert-Butyl 3-{2-[2-(2-acetylaminoethyl)-5-fluorophenoxy]ethoxy}-4-{4-[3-(3-fluorophenoxy)propoxy]phenyl}piperidine-1-carboxylate	HCID 68505109	—

Reaction Steps

Analogously to Method I, 0.26 g of tert-butyl 3-{2-[2-(2-acetylaminoethyl)-5-fluorophenoxy]ethoxy}-4-(4-hydroxyphenyl)piperidine-1-carboxylate and 0.153 g of 1-(3-bromopropoxy)-3-fluorobenzene are reacted. The title compound is obtained as a yellowish oil. Rf=0.41 (EtOAc); Rt=5.66.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07790715B2
Source dataset	uspto-grants-2010_09
ORD ID	ord-d0391636d22e4cc39a2e73b706f0f4f2
Source note	uspto-grants-2010_09