HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[2-(4-fluoro-2-hydroxyphenyl)ethyl]acetamide → tert-Butyl 3-{2-[2-(2-acetylaminoethyl)-5-fluorophenoxy]ethoxy}-4-(4-benzylphenyl)piperidin-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[2-(4-fluoro-2-hydroxyphenyl)ethyl]acetamide | HCID 68502030 | — |
| Reactant | Tert-butyl 4-(4-benzyloxyphenyl)-3-[2-(toluene-4-sulphonyloxy)ethoxy]piperidine-1-carboxylate | HCID 86610016 | — |
| Product | tert-Butyl 3-{2-[2-(2-acetylaminoethyl)-5-fluorophenoxy]ethoxy}-4-(4-benzylphenyl)piperidin-1-carboxylate | HCID 86610015 | — |
Reaction Steps
Analogously to Method G, 6.7 g of tert-butyl 4-(4-benzyloxyphenyl)-3-[2-(toluene-4-sulphonyloxy)ethoxy]piperidine-1-carboxylate and 4.54 g of N-[2-(4-fluoro-2-hydroxyphenyl)ethyl]acetamide (Example 112b) are reacted. The title compound is obtained as a yellowish oil. Rf=0.16 (2:1 EtOAc-heptane); Rt=5.44.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790715B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-158298e4627c4c2891ada5edbd8f4130 |
| Source note | uspto-grants-2010_09 |