Allyl bromide → HCID 86610017, compound

HRID 1712525Notes

Reaction equation

C(O[C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17][CH:16]2[OH:28])=[CH:11][CH:10]=1)C1C=CC=CC=1.[CH2:29](Br)[CH:30]=[CH2:31]>>[CH2:29]([O:28][CH:16]1[CH:15]([C:12]2[CH:13]=[CH:14][C:9]([CH2:15][C:12]3[CH:13]=[CH:14][CH:9]=[CH:10][CH:11]=3)=[CH:10][CH:11]=2)[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:25])([CH3:27])[CH3:26])=[O:22])[CH2:17]1)[CH:30]=[CH2:31]

Participants

Reactant 2

HCID 7841Allyl bromide

HCID 53401373HCID 53401373, compound

Product 1

HCID 86610017HCID 86610017, compound

Procedure

Analogously to Method D, 12 g of tert-butyl 4-(4-benzyloxyphenyl)-3-hydroxypiperidine-1-carboxylate and 5.4 ml of allyl bromide are reacted. The title compound is obtained as a yellowish oil. Rf=0.31 (1:3 EtOAc-heptane); Rt=5.80.

Sources & evidence

ORD record: ord-d8998e79e48c4766889761a6692eed4d
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07790715B2

Reaction notes

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