Methyl 2-amino-3-nitrobenzoate → 2,3-Diaminobenzoic acid methyl ester

Participants

Reaction Steps

10.10 g of methyl 2-amino-3-nitrobenzoate are suspended in 250 ml of methanol. 10% Pd/C (1.08 g) is added under argon and the reaction mixture is hydrogenated at room temperature at atmospheric pressure over 3 hours. The catalyst is filtered off through Hyflo and the filtrate is concentrated by evaporation. The title compound is isolated as a brown solid. Rt=2.15.

Provenance & Evidence