Hydrochloric Acid → HCID 68501061, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of 1.03 g of methyl 4-(1-benzyloxycarbony-4-{4-[3-(2-methoxybenzyloxy)-propoxy]phenyl}piperidin-3-yloxymethyl)-1-(2-trimethylsilanylethoxymethyl)-1H-benzoimidazole-2-carboxylate, 10 ml of methanol and 10 ml of 2M HCl is stirred at 50° C. over 2 hours. The reaction mixture is cooled, poured onto aqueous 1M sodium hydrogencarbonate solution (70 ml) and extracted with tert-butyl methyl ether (2×100 ml). The organic phases are washed with brine, dried over sodium sulphate and concentrated by evaporation. The title compound is obtained as a white foam from the residue by means of flash chromatography (SiO2 60F). Rf=0.26 (2:1 EtOAc-heptane); Rt=5.11.

Provenance & Evidence