N,N-Dimethylglycine → HCID 57470854, compound

Participants

Reaction Steps

N,N-Dimethylglycine (2.97 g), 1-hydroxybenzotriazole (3.89 g) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (5.27 g) were added to a solution of 4-(tert-butoxycarbonylamino)piperidine (5.0 g) in N,N-dimethylformamide (70 ml), followed by stirring at room temperature under a nitrogen atmosphere for 46 hours. Ethyl acetate (400 ml), brine (200 ml) and a 1N aqueous solution of sodium hydroxide (50 ml) were added to the reaction mixture, followed by stirring at room temperature for 30 minutes, and the mixture was partitioned. The aqueous layer was extracted with ethyl acetate. The organic layer was collected, washed with a 1N aqueous solution of sodium hydroxide and brine in this order, and dried over anhydrous sodium sulfate. The dried organic layer was concentrated under reduced pressure to give the title compound (8.03 g, quant.) as white crystals.

Provenance & Evidence