Trifluoroacetic acid → 3-(Hydroxymethyl)azetidine trifluoroacetate

Participants

Reaction Steps

Trifluoroacetic acid (0.413 ml) was added to tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate (125 mg) with cooling in an ice bath, followed by stirring at the same temperature for 30 minutes. Then the reaction mixture was stirred at room temperature for 1.5 hours. The reaction mixture was concentrated to give a crude product of the title compound (209.8 mg) as a yellow oil.

Provenance & Evidence