Benzyl Alcohol → 1-(Benzyloxy)-2,5-difluoro-4-nitrobenzene

Participants

Reaction Steps

Potassium carbonate (11.1 g) was added to a solution of 2,4,5-trifluoronitrobenzene (9.48 g) and benzyl alcohol (5.54 ml) in N,N-dimethylformamide (40 ml), followed by stirring at room temperature for 60 hours. Water (120 ml) was added to the reaction mixture at 0° C., followed by stirring at 4° C. for 24 hours. The precipitated crystals were collected by filtration, and washed with water. The crystals were dried under reduced pressure to give the title compound (11.5 g, 81%) as pale yellow crystals.

Provenance & Evidence