Methanol → HCID 24788497, compound

Participants

Reaction Steps

Benzyl 1-[({2,5-difluoro-4-[(2-{[((R)-3-hydroxypyrrolidin-1-yl)carbonyl]amino}pyridin-4-yl)oxy]phenyl}amino)carbonyl]cyclopropanecarboxylate (156.8 mg) was dissolved in tetrahydrofuran and methanol (2:1) (6 ml) under a nitrogen atmosphere. 10% palladium on carbon (68.6 mg) was added, and the air in the reaction vessel was replaced by hydrogen, and the mixture was stirred at room temperature for 16 hours and 30 minutes. The air in the reaction vessel was replaced by nitrogen, and triethylamine (0.112 ml) was added, and the mixture was stirred for 30 minutes. The catalyst was removed by filtration, and washed with methanol. The filtrate was concentrated under reduced pressure to give the title compound (185.3 mg, quant.) as a white solid.

Provenance & Evidence