HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178526521, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzenepropanoic acid, 4-nitro-beta-oxo-, ethyl ester | HCID 13281 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178526521 | HCID 178526521 | — |
Reaction Steps
According to method of U.S. Pat. No. 3,781,438, 2 g of ethyl 3-(4-nitrophenyl)-3-oxopropanoate was dissolved in methanol, slightly excessive hydroxylamine hydrochloride and equivalent amount of sodium hydroxide were added, the mixture was heated to reflux. 3 hr later, the reaction was traced by Thin-Layer Chromatography, water was added to the reaction mixture, extracted with ethyl acetate, dried and concentrated to obtain 3-(4-nitrophenyl)isoxazol-5-ol as solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795179B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-6acd240b804446e9aad2b60b253295ec |
| Source note | uspto-grants-2010_09 |