Acetophenone → HCID 8854025, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-6-fluorobenzaldehyde (0.599 g, 3.8 mmol) and 1-phenylethanone (0.414 mL, 0.38 mmol) in piperidine (1 mL) was heated at 100° C. for 1 h. The reaction mixture was allowed to cool to rt and was concentrated. The residue was purified by column chromatography to give (2E)-3-(2-chloro-6-fluorophenyl)-1-pyridin-3-ylprop-2-en-1-one (0.28 g, 28%).

Provenance & Evidence