反应详情

温度

95 °C

A mixture of 2-phenyl-5-(trifluoromethyl)-1H-imidazole (47.1 mmol) and NaOH (63.8 mmol) in water (20 mL) was allowed to stir at 95° C. overnight. The reaction mixture was allowed to cool to rt and was diluted with water and extracted with DCM. The pH of the aqueous solution was adjusted to pH=7 with 1N HCl and the solution was extracted again with DCM. The aqueous solution was concentrated to give 2-phenyl-1H-imidazole-5-carboxylic acid as a white solid which was used without further purification.

1. temperatureto cool to rt
2. extractionextracted with DCM
3. extractionthe solution was extracted again with DCM
4. concentrationThe aqueous solution was concentrated