Sodium Hydroxide → HCID 59463148, compound

Participants

Reaction Steps

To a solution of 5-(pyridine-2-ylethynyl)thiophene-2-carboxylate (1.43 g, 5.54 mmol) in ethanol (40 mL) was added sodium hydroxide (0.585 g, 14.6 mmol). The reaction mixture was allowed to stir at rt for 20 h. The solution was concentrated and diluted with 1N aqueous HCl. A precipitate formed and was filtered to give 5-(pyridine-2-ylethynyl)thiophene-2-carboxylic acid (1.02 g, 4.46 mmol) as a yellow solid. LCMS: (FA) ES+ 230.2, ES-229.4.

Provenance & Evidence