HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1712932Generated: October 31, 2026
Potassium Carbonate → HCID 68708425, compound
https://huagongshe.com/reaction/1712932
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | 2-Iodobenzonitrile | HCID 2759358 | — |
| Reactant | HCID 178418785 | HCID 178418785 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 68708425 | HCID 68708425 | — |
Reaction Steps
A mixture of methyl 1H-imidazole-4-carboxylate (400 mg, 0.003 mol), 2-iodobenzonitrile (800 mg, 0.0035 mol), L-proline (0.073 g, 0.00063 mol), potassium carbonate (0.88 g, 0.0063 mol) and copper(I) iodide (0.060 g, 0.00032 mol) in DMSO (8 mL) was allowed to stir and heated at 90° C. in a sealed tube overnight. The mixture was diluted with EtOAc, washed with water and brine, dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography to afford methyl 1-(2-cyanophenyl)-1H-imidazole-4-carboxylate. LCMS: (FA) ES+ 228.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07795249B2 |
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| Source dataset | uspto-grants-2010_09 |
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| ORD ID | ord-f2186df6c0084a5f98ad69b9a9dddd1a |
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| Source note | uspto-grants-2010_09 |
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