HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 4-Bromoisoindolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Methyl 3-bromo-2-(bromomethyl)benzoate | HCID 21907554 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Bromoisoindolin-1-one | HCID 21907509 | 91% |
Reaction Steps
To a solution of methyl 3-bromo-2-(bromomethyl)benzoate (27 mmol) in THF (100 mmol) was added ammonium hydroxide (9 mL) dropwise at rt. The reaction mixture was allowed to stir overnight and then diluted with 30 mL of water. The solution was extracted with DCM, dried over Na2SO4, filtered and concentrated to give 4-bromoisoindolin-1-one (5.20 g, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795249B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-b1650367a16449beb60bcaef47cf07d9 |
| Source note | uspto-grants-2010_09 |