HuagongsheHuagongshe Chemistry Print Report · For research reference only
Di-tert-butyl dicarbonate → Tert-butyl (2-bromo-5-methoxybenzyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Reactant | (2-Bromo-5-methoxyphenyl)methanamine | HCID 24691009 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Tert-butyl (2-bromo-5-methoxybenzyl)carbamate | HCID 22930485 | 96.9% |
Reaction Steps
To a solution of 1-(2-bromo-5-methoxyphenyl)methanamine (3.2 mmol) in DCM (15 mL) was added BOC2O (3.2 mmol). The reaction mixture was allowed to stir at rt overnight and then concentrated. The residue was purified by column chromatography to give tert-butyl (2-bromo-5-methoxybenzyl)carbamate (3.1 mmol, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795249B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-70f8d574887042aabeef4e1eeace8023 |
| Source note | uspto-grants-2010_09 |