反应详情

To a solution of 2-(3-pyridin-3-yl-4,5-dihydro-1H-pyrazol-5-yl)phenol (600 mg, 2.51 mmol) and pyridine-2-ylthiophene-2-carboxylic acid (515 mg, 2.51 mmol) in DCM (10 mL) was added EDCI (580 mg, 3.00 mmol) and DMF (3 mL). After stirring for 12 h, water and EtOAc were added. The resulting solid was filtered and washed with EtOAc and cold MeOH and dried under vacuum to give 2-[3-pyridin-3-yl-1-[(5-pyridin-2-yl-2-thienyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-yl]phenol (I-76) (520 mg, 49%). LCMS: (AA) ES+ 427.4.

1. filtrationThe resulting solid was filtered
2. washwashed with EtOAc and cold MeOH
3. customdried under vacuum