Hydrochloric Acid → HCID 54586652, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-{3-(5-{[(4-methoxybenzyl)oxy]methyl}pyridin-3-yl)-1-[(5-pyridin-2-yl-2-thienyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-yl}phenol (0.070 g, 0.12 mmol) in MeOH (6 mL) was added HCl. The reaction mixture was allowed to stir at 65° C. for 6 h and then at rt overnight. Reaction was incomplete, so the mixture was allowed to stir at 65° C. for an additional 10 h and then cooled to rt and concentrated. The residue was purified by column chromatography to give 2-{3-[5-(hydroxymethyl)pyridin-3-yl]-1-[(5-pyridin-2-yl-2-thienyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-yl}phenol (I-273). LCMS: (FA) ES+ 457.4, ES-455.5.

Provenance & Evidence