Sodium Azide → HCID 59463204, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-{[5-(2-hydroxyphenyl)-3-pyridin-3-yl-4,5-dihydro-1H-pyrazol-1-yl]carbonyl}thiophene-2-carbonitrile (0.300 g, 0.60 mmol) in DMF (5 mL) was added sodium azide (0.120 g, 1.80 mmol) and aluminum trichloride (0.240 g, 1.80 mmol). The reaction mixture was allowed to stir at 100° C. overnight and then concentrated. The residue was purified by column chromatography to give 2-(3-pyridin-3-yl-1-{[5-(2H-tetrazol-5-yl)-2-thienyl]carbonyl}-4,5-dihydro-1H-pyrazol-5-yl)phenol (I-226). LCMS: (FA) ES+ 436, ES-434.

Provenance & Evidence