HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1713024Generated: November 3, 2026
Water → 4-[2-(4-chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyric acid
https://huagongshe.com/reaction/1713024
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyric acid ethyl ester | HCID 11697991 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 4-[2-(4-chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyric acid | HCID 11567896 | 83.4% |
Reaction Steps
Compound 10 (1.21 grams, 2.3 mmol) was dissolved in TFA (33 ml), water (11 ml) was added thereto, and the resulting mixture was heated at 90° C. for 16 hours. The product was filtered and washed with ethanol to give Compound 11 (800 mg, 83% yield) as an orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07795255B2 |
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| Source dataset | uspto-grants-2010_09 |
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| ORD ID | ord-5da72067659847e4ac8958036437e9cb |
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| Source note | uspto-grants-2010_09 |
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