HCID 86618333, compound → HCID 68504318, compound

HRID 1713031Notes

Reaction equation

HRID 1713031 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[C:5]([N:22]=[N+]=[N-])=[CH:6][C:7]1[O:8][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)=[CH:10][CH:11]=1)[CH3:2]>CC1C=CC(C)=CC=1>[CH2:1]([O:3][C:4]([C:5]1[NH:22][C:11]2[CH:10]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=3)[O:8][C:7]=2[CH:6]=1)=[O:25])[CH3:2]

Participants

3

Reactant 1

HCID 86618333HCID 86618333, compound

Product 1

HCID 68504318HCID 68504318, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 7809P-XyleneSolvent

Procedure

The isolated 2-azido-3-[5-(3-trifluoromethyl-phenyl)-furan-2-yl]-acrylic acid ethyl ester was heated to 125° C. in p-xylene (5 ml) for 1 hour. The solvent was thereafter evaporated under reduced pressure to give 39.6 mg (96% yield) of 2-(3-trifluoromethyl-phenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester as a brownish solid.

Workup

  1. customThe solvent was thereafter evaporated under reduced pressure

Sources & evidence

ORD record
ord-ba9cfbf1090d43e383417895e7194d66
Source dataset
uspto-grants-2010_09
Patent number
US07795255B2

Reaction notes

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