Hexane → HCID 11538914, compound

Participants

Reaction Conditions

Reaction Steps

Compound 31 (20 mg, 0.046 mmol) was dissolved in a mixture of TFA and water (4:1, 2 ml) and the resulting solution was heated at 70° C. for 5 hours, while monitoring the reaction progress by TLC using a 6:4 hexane:ethyl acetate mixture as eluent. The mixture was cooled to room temperature and left intact for one hour. The formed precipitate was thereafter filtered and washed with small portions of ethanol. The crude residue was recrystallized from ethanol to give pure Compound 32 (10 mg, 56% yield).

Provenance & Evidence