Trifluoroacetic acid → HCID 67532753, compound

Participants

Reaction Steps

Trifluoroacetic acid (20 ml) was added to a solution of Example 3 (5.4 g, 11.0 mmol) in DCM (20 ml) and stirred at r.t. for 5 h. NaHCO3(aq) (200 ml) was added to the reaction, and the mixture extracted with DCM (3×100 ml). The combined organic extracts were dried (MgSO4) and concentrated in vacuo. The crude product was purified by chromatography (silica, 10% THF in DCM) to give the title compound as a yellow solid (3.0 g, 76%). δH (CDCl3) 7.52-7.45 (3H, m), 7.33-7.30 (6H, m), 6.72 (1H, d, J 9.6 Hz), 6.33 (1H, d, J 9.6 Hz), 2.35 (3H, s). LCMS (ES+) RT 3.11 minutes, 361 (M+H)+.

Provenance & Evidence