1-Benzyl-4-piperidone → 1-Benzyl-4-(1-pyrrolidinyl)-1,2,3,6-tetrahydropyridine

Participants

Reaction Steps

A mixture of 1-benzyl-4-piperidone (7.2 g, 39.64 mmol), and pyrrolidine (4.23 g, 59.5 mmol) in toluene (50 mL) is refluxed for 4 hr with a Dean-Stark trap to remove water. The mixture is cooled to rt and removal of solvent in vacuo provides the title compound as a light orange oil, which is used in the next step without further purification.

Provenance & Evidence